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Over the last three decades, cold atmospheric plasma (CAP) has been heavily investigated in a wide range of biological applications, including wound healing, microorganism sterilization, and cancer treatment. Atmospheric pressure plasma jets (APPJs) are the most common plasma sources in plasma medicine. An APPJ’s size determines its application range and approach in treatment. In this study, we demonstrated the real-time recognition of an APPJ’s plasma plume output using computer vision (CV), dramatically improving the measurement speed compared to the traditional method of using the naked eye. Our work provides a framework to monitor an aspect of an APPJ’s performance in real time, which is a necessary step to achieving an intelligent CAP source. 

CAP is an ionized gas generated under atmospheric pressure conditions. Due to its reactive chemical components and near-room temperature nature, CAP has promising applications in diverse branches of medicine, including microorganism sterilization, biofilm inactivation, wound healing, and cancer therapy. Currently, hundreds of in vitro demonstrations of CAP-based cancer treatments have been reported. However, preclinical studies, particularly in vivo studies, are pivotal to achieving a final clinical application. Here, we comprehensively introduced the research status of the preclinical usage of CAP in cancer treatment, by primarily focusing on the in vivo studies over the past decade. We summarized the primary research strategies in preclinical and clinical studies, including transdermal CAP treatment, post-surgical CAP treatment, CAP-activated solutions treatment, and sensitization treatment to drugs. Finally, the underlying mechanism was discussed based on the latest understanding. 

Cold atmospheric plasma (CAP) is a tunable source of reactive species and other physical factors. It exerts luxuriant biochemical effects on diverse cells, including bacterial cells, mammalian cells, and plant cells. Over the past decade, CAP has shown promising application in modern agriculture. Here, we focused on the state of the art of plasma agriculture, particularly the improvement of seed germination rates. Typical plasma sources, underlying physical principles, and the chemical and cellular mechanism of plasma’s effect on plants seeds have been discussed in depth. 

In this study, we demonstrated that the widely used cold atmospheric plasma (CAP) jet could significantly inhibit the growth of melanoma cells using a contactless treatment method, The flow rate of helium gas was a key operational parameter to modulate electromagnetic (EM) effect on melanoma cells. Metal sheets with different sizes could be used as a strategy to control the strength of EM effect. More attractive, the EM effect from CAP could penetrate glass/polystyrene barriers as thick as 7 mm. All these discoveries presented the profound non-invasive nature of a physically based CAP treatment, which provided a solid foundation for CAP-based cutaneous/subcutaneous tumor therapy. 

Cold atmospheric plasma (CAP) is an ionized gas, the product of a non-equilibrium discharge at atmospheric conditions. Both chemical and physical factors in CAP have been demonstrated to have unique biological impacts in cancer treatment. From a chemical-based perspective, the anti-cancer efficacy is determined by the cellular sensitivity to reactive species. CAP may also be used as a powerful anti-cancer modality based on its physical factors, mainly EM emission. Here, we delve into three CAP cancer treatment approaches, chemically based direct/indirect treatment and physical-based treatment by discussing their basic principles, features, advantages, and drawbacks. This review does not focus on the molecular mechanisms, which have been widely introduced in previous reviews. Based on these approaches and novel adaptive plasma concepts, we discuss the potential clinical application of CAP cancer treatment using a critical evaluation and forward-looking perspectives.